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Loading, please waitCondition — Musculoskeletal
Knee osteoarthritis (gonarthrosis, ICD-10 M17) is the progressive wear of the cartilage that covers the femur, tibia and patella. At Regeneris Therapy we combine current clinical evidence and regenerative medicine to reduce pain, improve mobility and, in selected cases, postpone or avoid total knee replacement.
Knee osteoarthritis is the most common form of joint degeneration in adults. It starts with morning stiffness, clicking and a mechanical pain that shows up when walking, climbing stairs or squatting. Over time the cartilage thins, exposing subchondral bone, osteophytes (bone spurs) appear and the knee loses its shock-absorbing capacity. The clinical result is a joint that hurts at rest, limits walking and silently erodes quality of life.
It is not an inevitable consequence of aging. Several factors combine: genetic predisposition, excess weight, previous meniscal or ligament injury, knee alignment (varus or valgus), quadriceps weakness and an underlying metabolic-inflammatory pattern. Understanding them in a frank medical evaluation is the foundation of a plan that actually works, instead of applying the same protocol to every patient.
Regeneris Therapy operates under a COFEPRIS aviso de funcionamiento and partners with licensed Mexican laboratories for the processing of cellular products. Our medical team, led by Dr. Claudia Labastida, assesses each case with x-rays, the Kellgren-Lawrence scale, functional examination and, when needed, MRI. We only recommend a regenerative protocol when clinical evidence supports a realistic benefit for your grade of osteoarthritis.
This page is informational and does not replace a medical consultation. Every plan at our Cancún clinic is built on an individual evaluation: your history, your imaging, your goals. If knee-replacement surgery has already been suggested, that may also make sense — and we will tell you honestly.
Knee osteoarthritis is multifactorial. It used to be described as simple wear-and-tear; today we understand it as an active process in which low-grade inflammation, mechanical stress and metabolic changes feed each other. Cartilage cannot regenerate at the pace at which it is damaged, and each new inflammatory episode accelerates degradation.
The best-documented risk factors are: age over 45, female sex (especially after menopause, due to declining estrogen), overweight and obesity (every extra kilogram quadruples the load on the knee when walking), prior meniscal or anterior cruciate ligament injury, repetitive high-impact sport, varus or valgus alignment, chronic quadriceps weakness and metabolic disease such as type-2 diabetes or hyperuricemia.
Recent evidence highlights the role of the 'inflammatory terrain': patients with metabolic syndrome, insulin resistance or pro-inflammatory diets show faster progression and a poorer response to treatment. That is why our approach at Regeneris Therapy is not limited to the knee: optimizing metabolism, weight and muscle strength is part of the plan.
Regenerative medicine for the knee is not a magical cure: it is a group of supportive therapies, complementary to medical care, that can slow progression, reduce pain and improve function in selected patients. Evidence is strongest in Kellgren-Lawrence grades I through III; in grade IV (bone-on-bone) joint replacement usually remains the definitive treatment and we will say so honestly.
The three main tools are mesenchymal stem cells (MSCs), platelet-rich plasma (PRP) and exosomes. MSCs have documented immunomodulatory and anti-inflammatory effects inside the joint; PRP releases growth factors that stimulate tissue repair; exosomes — nanoscale vesicles — deliver regenerative signals without the cell-viability concerns of cellular therapies. Each protocol is selected based on your grade of osteoarthritis, age, weight and functional goals.
In every case, the intra-articular injection is just one piece of the plan. We combine it with metabolic evaluation, targeted quadriceps rehabilitation, nutritional recommendations and, when relevant, IV therapy with vitamins and antioxidants to reduce the systemic inflammatory terrain. The best results occur when the patient commits to all four fronts: inflammation, metabolism, movement and lifestyle.
Linked protocols
Dedicated protocol for knee osteoarthritis with MSCs, PRP and targeted rehabilitation. Includes medical evaluation, imaging and a personalized plan.
Stand-alone intra-articular injection service (PRP, hyaluronic acid, MSCs or exosomes) under clinical guidance in our procedure room.
Let's be honest: osteoarthritis is a chronic disease and there is no definitive cure. What we can offer in well-selected patients is clinically meaningful improvement in pain and function, sustained for months or years, that may postpone or avoid surgery. Most patients report noticeable improvements between weeks 4 and 12, with cumulative benefits typically peaking between months 3 and 6.
Factors that improve prognosis include grade I-III osteoarthritis, a healthy body weight or willingness to reach one, absence of severe joint deformity, good quadriceps strength (or willingness to train it), metabolic control (diabetes, dyslipidemia) and adherence to the rehabilitation plan. Factors that predict less response include uncontrolled major obesity, grade IV osteoarthritis with severe malalignment, untreated systemic comorbidities and expecting an instant result with no lifestyle commitment.
At Regeneris Therapy our goal is not to sell procedures: it is to give you the best path for your case. If the evidence supports regenerative medicine for you, we propose a concrete plan. If your case requires a knee replacement or an orthopedic evaluation, we will tell you directly — and, if you wish, refer you to trusted colleagues in Cancún.
Current evidence suggests mesenchymal stem cells exert a primarily anti-inflammatory and immunomodulatory effect inside the joint, which translates into improvements in pain and function. Some MRI studies show improved cartilage signal in selected patients, but we should not promise 'full regeneration'. The realistic goal is to slow progression and improve your quality of life, not give you back a 25-year-old knee.
Revisado por Dr. Claudia Labastida · 2026-05-18
For grades I-III it often is: many patients postpone surgery by five years or more, or avoid it altogether when they also control the other factors (weight, strength, metabolism). For advanced grade IV osteoarthritis with bone-on-bone changes and severe malalignment, joint replacement remains the most effective long-term treatment and we will say so honestly during your evaluation.
Revisado por Dr. Claudia Labastida · 2026-05-18
Most patients notice perceptible improvement between weeks 2 and 4, with a peak at months 3-6. It is not an instant effect: regenerative products work by modulating the joint environment, and that takes time. We schedule follow-up consultations at one month, three months and six months to measure progress objectively.
Revisado por Dr. Claudia Labastida · 2026-05-18
Intra-articular injection is performed under local anesthesia; most patients describe a mild-to-moderate discomfort lasting a few seconds. Risks are typical of any joint procedure: post-injection pain or swelling for 24-72 hours, localized hematoma and, very rarely, infection. We use sterile technique and, when applicable, ultrasound guidance for maximum precision.
Revisado por Dr. Claudia Labastida · 2026-05-18
Most patients return to work the next day. We recommend avoiding heavy impact (running, jumping) for the first two weeks, keeping gentle walking and stationary cycling, and restarting progressive quadriceps strengthening under physical-therapy guidance. The rehabilitation plan is delivered in writing at your post-procedure follow-up.
Revisado por Dr. Claudia Labastida · 2026-05-18
We work exclusively with cellular products processed in licensed Mexican laboratories with COFEPRIS authorization, with documented traceability from donor to application. The allogeneic MSCs we use are derived from umbilical cord, an internationally recognized source for its safety profile and immunomodulatory capacity. Source documentation is available for review during your consultation.
Revisado por Dr. Claudia Labastida · 2026-05-18
Cost varies depending on the biological product (PRP, MSCs, exosomes), the number of joints treated and whether adjunctive IV therapy is included. After the medical evaluation we provide a clear written quote, with no surprises. We do not publish fixed prices because each case needs a different plan — honesty is preferable to a marketing hook.
Revisado por Dr. Claudia Labastida · 2026-05-18
A prior prosthesis is not a contraindication. Significant excess weight does not prevent treatment but reduces its efficacy: every extra kilogram increases joint load. That is why, together with the injection, we include a metabolic and nutritional plan. If your case first requires a more urgent intervention (for example controlling severe diabetes), we will tell you before proceeding.
Revisado por Dr. Claudia Labastida · 2026-05-18
Scientific evidence
This bibliography is provided for educational purposes. It does not constitute medical advice and does not imply that any cited study endorses Regeneris Therapy or guarantees a clinical outcome.
Explore current evidence on stem cell therapy for knee osteoarthritis, how MSCs work in joints, ideal candidates, and what to expect from treatment in Mexico.
An honest comparison between surgical and regenerative approaches for joint, tendon, and musculoskeletal problems. When each option makes clinical sense and what questions to ask.
A complete guide to platelet-rich plasma (PRP) therapy: how it works, clinical indications, what to expect, and why it is a popular option in regenerative medicine.
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Every case starts with an honest medical evaluation at our Cancún clinic. We will review your x-rays, your history and your expectations, and tell you frankly whether regenerative medicine is your best option or whether another path makes more sense. No pressure, no empty promises.